Short-reads Whole Genome Sequencing
What is Whole Genome Sequencing
Whole Genome Sequencing is the analysis of the entire genome, including intronic and
exonic regions of DNA.
Dante Genomics provides 30X coverage for the whole genome which means 30X on average on the exonic and intronic region of the genome. This is considered the best coverage which allows for the detection of rare variants on single nucleotide polymorphisms (SNPs) with more accuracy.
For what purpose is it useful
- The data provided thanks to this method can be used to identify all the genetic variations in the genome, including non-coding and structural variants.
- WGS is very useful to investigate inherited disorders and rare diseases, to develop targeted therapies and drugs for fighting their progression.
What genes can it be used for
The WGS application can be extended to non-human genomes, for example for agricultural or bacteria segments, in fact it was widely used during the Covid-19 pandemic.
Technology used for the analysis
The analysis is powered by Next Generation Sequencing (NGS) technology, a powerful tool for research and clinics that can reduce costs in terms of money and time, and that can drive to terabytes of output.
What information do you get
Extensa software, which is both CE-IVD and ISO13485 certified, is the Dante Labs property system that intervenes in the bioinformatic process.
The result is a comprehensive overview of the whole genome, with the highest level of accuracy and precision.
What type of raw data provides
You can choose for:
- FASTQ: this file format contains the raw sequencing data, including the base calls and quality scores for each read. It is a standard format used in Next-Generation Sequencing and can be used to analyse the data using various bioinformatics tools.
You can also add:
- VCF: this file format contains the variant calls, or differences between the individual's genome and a reference genome. It includes information such as the type of variant, the location in the genome, and any associated annotation data.
- BAM: this file format is a binary version of a SAM (Sequence Alignment/Map) file, which contains the aligned reads of the sequencing data to a reference genome. It is usually used for downstream analysis such as variant calling and annotation.
We provide more than 100 panels for a wide range of needs and opportunities.
Thanks to our panels you will be able to transform DNA Data into complete information to guide some of the most critical decisions in your patients' lives. You can also customize the panels you need for yourself or your patient.
You can purchase all the panels within the Genome Manager Platform in the "Shop" section or you can upload your raw data into our Avanti software and purchase the panels of interest directly within it.