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Dante Genomics

Solid Tumor Sequencing Test (500 genes)

Solid Tumor Sequencing Test (500 genes)

TSO 500 test allows to detect cancer-related genes starting from DNA and RNA extracted from formalin-fixed paraffin embedded (FFPE) tissue. The test is optimized to provide high sensitivity and specificity for low-frequency somatic variants across 523 genes. DNA biomarkers include Single nucleotide variants (SNVs), Insertions, Deletions, Gene amplifications, Multinucleotide variants (MNVs).

TSO 500 also detects immunotherapy biomarkers for tumor mutational burden (TMB) and microsatellite instability (MSI) in DNA. Fusions and splice variants are detected in RNA.

Bioinformatics

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TUMOR SAMPLE REQUIREMENTS

To ensure accurate molecular profiling, please follow the specimen guidelines below when submitting tumor samples.

TISSUE REQUIREMENTS:

  • 1 FFPE block with the greatest tumor content

Otherwise:

  • 5 FFPE unstained slide for NGS 5 μm sections (minimum)*
  • Terminal 1 H&E stained slide

*Submit additional slides if tissue size is small (<30 mm2 or < 0.14 mm3), to allow a second analysis in case of unqualified sample: 6 FFPE unstained slide for NGS 5 μm sections.

Optimal tumor size: 30 mm2; minimum: 14 mm2 (minimum volume 0.14 mm3)

The patient material should be labeled with an identifier.

Tumor samples should be from the most recent procedure, if adequate for testing, and must be less than 6 years old.

Tumor required to be at least 25% of the sample.

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